Automatic assignment of GO terms using logical inference, based on on inter-ontology links
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
UniProt record for donkey SNAP23 (A0A8C4M285)
UniProt record for human SNAP23 (O00161)
SNAP23: donkey-human sequence comparison
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The donkey product is truncated after the palmitoylated linker and lacks the second SNARE motif.
"The product lacks the human region 90..211, which includes the C-terminal t-SNARE coiled-coil motif (Qc, human 146..208)."
SNAP23 (donkey) re-review: gene-model and family placement
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The benchmark product comes from an alternative-terminal-exon transcript of the single donkey SNAP23 gene; the gene-centric canonical product is A0A8C4M333.
"The benchmark product is therefore an alternative-splice (alternative terminal exon) gene model, not a separate gene."
Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues.
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SNAP23 binds multiple syntaxins and VAMPs and, unlike SNAP25, is expressed in all tissues.
"Unlike SNAP-25, SNAP-23 was expressed in all tissues examined."
Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain.
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The isolated N-terminal SNARE motif of SNAP23 assembles with the separate C-terminal motif, syntaxin-4 and VAMP-3 into a heterotetramer, and alone forms a homotetramer.
"SNAP-23N can assemble spontaneously with the coiled-coil domains from SNAP-23C, syntaxin-4, and VAMP-3 to form a heterotetrameric complex."
Syntaxin 11 regulates the stimulus-dependent transport of Toll-like receptor 4 to the plasma membrane by cooperating with SNAP-23 in macrophages.
Differential control of the releasable vesicle pools by SNAP-25 splice variants and SNAP-23.
Differential abilities of SNAP-25 homologs to support neuronal function.
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In Snap25-null neurons, SNAP23 rescues survival and spontaneous release but supports only asynchronous evoked release.
"SNAP-23 supported asynchronous release only"