Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300.
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity.
Arginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determination.
Two overlapping divergent transcription units in the human genome: the FEN1/C11orf10 locus.
WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork.
Stimulation of flap endonuclease-1 by the Bloom's syndrome protein.
Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease-1.
Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1.
A protein domain-based interactome network for C. elegans early embryogenesis.
Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates.
Purification of proteins associated with specific genomic Loci.
Defining the membrane proteome of NK cells.
Human MUS81 complexes stimulate flap endonuclease 1.
A quantitative telomeric chromatin isolation protocol identifies different telomeric states.
Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function.
A fluorescent bimolecular complementation screen reveals MAF1, RNF7 and SETD3 as PCNA-associated proteins in human cells.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1.
R152C DNA Pol β mutation impairs base excision repair and induces cellular transformation.
Architecture of the human interactome defines protein communities and disease networks.
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Maximizing binary interactome mapping with a minimal number of assays.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Flap Endonuclease 1 Endonucleolytically Processes RNA to Resolve R-Loops through DNA Base Excision Repair.
Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I.
Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage.
The characterization of a mammalian DNA structure-specific endonuclease.
Essential amino acids for substrate binding and catalysis of human flap endonuclease 1.
The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21.
Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity.
FEN1 bound to PCNA and APEX1 cleaves flap ssDNA
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1
POLD,POLE-mediated DNA strand displacement synthesis
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Removal of remaining Flap from the C-strand
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site
POLB-mediated DNA strand displacement synthesis
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate
PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB
FEN1 bound to POLB cleaves displaced DNA strand (flap)
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site
POLQ extends annealed 3'-ssDNA overhangs in MMEJ
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate
FEN1 cleaves displaced ssDNA flaps during MMEJ
Removal of remaining Flap