Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
UniProtKB flat-file record for Emericella nidulans sec11 (Q5B8K4)
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Q5B8K4 is a reviewed single-pass ER membrane Sec11/S26B-family signal peptidase complex catalytic subunit with conserved catalytic residues.
"FUNCTION: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum"
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The UniProt record places Q5B8K4 in PTHR10806 and its fungal SEC11 subfamily.
"PANTHER; PTHR10806:SF6; SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"
PANTHER PTHR10806 PAINT annotations
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PTHR10806 has a root peptidase-activity IBD and separate Eukaryota-scoped IBDs for the signal peptidase complex and protein maturation.
"PTHR10806 PTN000086749 GO:0008233 F IBD false SGD:S000001461|UniProtKB:P13679|UniProtKB:P67811|UniProtKB:P67812|UniProtKB:Q8IE14|UniProtKB:Q9BY50"
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The eukaryotic signal peptidase complex and protein maturation placements are both on PTN000086750.
"PTHR10806 PTN000086750 GO:0051604 P IBD false SGD:S000001461|UniProtKB:P67812|UniProtKB:Q9BY50 taxon:2759 20260528"
PANTHER PTHR10806 member entries
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A. nidulans Q5B8K4 and S. cerevisiae P15367 are both placed in PTHR10806:SF6, the fungal SEC11 subfamily.
"Q5B8K4,Signal peptidase complex catalytic subunit sec11,protein,227321,Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139),Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139),sec11,192,PTHR10806:SF6,SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11,True"
Effect of secretory pathway gene overexpression on secretion of a fluorescent reporter protein in Aspergillus nidulans.
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A. nidulans AN10354 was experimentally overexpressed as the S. cerevisiae SEC11 ortholog in a secretory-pathway engineering study.
"Sec63 (AN0834) and the ortholog of S. cerevisiae SEC11 (AN10354) were overexpressed (generating strains NID1600 and NID1608, respectively)."
The Sec11 C-terminal short helix promotes productive engagement of internal signal sequences with the signal peptidase complex.
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Yeast Sec11 is the conserved catalytic subunit of the signal peptidase complex.
"Sec11, the catalytic subunit of the SPC, contains an N-terminal transmembrane domain and a C-terminal hydrophobic region."
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The Sec11-containing signal peptidase complex cleaves signal sequences after ER targeting.
"Following targeting, these sequences are cleaved by the heterotetrameric signal peptidase complex (SPC)."