wry (Weary, CG31665, Q7KU08) curation notes

Deep research: wry-deep-research-falcon.md (falcon; the wrapper reported a 600 s timeout but the run completed later). Folded in as an EDIT; its conclusions agree with the review and it is cited in the core function.

Literature journal

• Identified in an adult cardiomyopathy deficiency screen; DSL-less Notch ligand
  PMID:20203305
• Transactivation blocked by gamma-secretase inhibitors
  PMID:20203305
• No sensory-organ or wing phenotypes in Wry deficiencies
  PMID:20203305

Curation decisions

• Core: receptor ligand activity + Notch binding in Notch signaling (consistent with Dl/Ser reviews).
• cell communication / signaling IEA MODIFY -> Notch signaling pathway (round-2 convention).
• ARBA neural/glial/morphogenesis terms marked over-annotated (no supporting evidence; deficiencies lack neural phenotypes).
• Single-study gene; PANTHER places it in the Crumbs family (PTHR24049), worth expert confirmation.