Electronic Gene Ontology annotations created by ARBA machine learning models
TreeGrafter-generated GO annotations
Annotation inferences using phylogenetic trees
TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes.
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Human TBC1D14 binds GTP-locked RAB11A/B selectively and has no detectable GAP activity against a panel of 47 Rabs; it localizes to recycling endosomes and moves to the Golgi on starvation.
"TBC1D14 binds specifically to both Rab11a and 11b but not to any of the other 55 Rabs tested"
TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic.
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TBC1D14 binds TRAPPIII via TRAPPC8 through an N-terminal region and is required for RAB1 activation and ATG9 trafficking; it acts as a negative regulator of autophagy.
"We also demonstrate that TBC1D14 is required for activation of RAB1 through its TRAPP‐binding ability."
Re-review sequence analysis of cod tbc1d14 (gene model, orthology, catalytic residues)
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All cod tbc1d14 entries are transcripts of ENSGMOG00000018292; A0A8C5FPT8 is an alternative model with a non-conserved N-terminus and a non-conserved 48-residue C-terminal tail; it groups with vertebrate TBC1D14, not TBC1D12, despite PANTHER SF15.
"A0A8C5FPT8 is therefore a near-complete alternative gene model."
Falcon deep research report for cod tbc1d14
UniProt record A0A8C5FPT8