Ar1 (M9PF61) notes

• Ar1 = Akr1B = CG6084, AKR1B-family aldose reductase.
• Polyol pathway glucose -> sorbitol -> fructose supports Mondo glucose sensing; AR double mutants (CG6084 + CG10638)
  reduce hemolymph sorbitol PMID:35687590.
• Hemocyte AR makes sugar alcohol alarmins for gut-fat body immune communication
  PMID:31350199.
• Akr1B is the PGF2alpha synthase needed in border cells PMID:38283991;
  cytoplasmic in follicle cells.

• Decisions: aldose reductase, sorbitol biosynthesis, fructose biosynthesis (polyol pathway), cytosol core; broad AKR
  activities (allyl/aryl alcohol, glycerol, retinol dehydrogenase, PGH2 reductase) non-core; AKR1A1-derived
  glucuronate terms and retinol metabolic process marked over-annotated; IDA extracellular region UNDECIDED.

• Falcon deep research (Ar1-deep-research-falcon.md) is consistent; it explains the IDA extracellular region row (Yang et al.
  describe AR as secreted and detect reductase activity in hemolymph) but notes secretion of intact Ar1 is not demonstrated,
  so the row stays UNDECIDED. It also mentions preprint-level evidence for a glial role.

• PR #4484 review: GO:0046173 polyol biosynthetic process (IMP) changed from MODIFY (to sorbitol biosynthesis) to ACCEPT, because the cited experiment measured both sorbitol and galactitol; PGF2alpha-synthase MF and BP rows now share one rationale (secondary, non-core).