Itpr3 (rat) review notes

• Fetched with just fetch-gene rat Itpr3; UniProt Q63269 (ITPR3_RAT, Swiss-Prot), RGD:2934, GeneID 25679. 95 GOA rows.
• No deep-research provider available; manual synthesis in Itpr3-deep-research-manual.md.
• Modelled decisions on the completed rat Itpr1 review for consistency.

Key decisions

• Core MF GO:0005220 accepted on all rows; general channel/transport MF terms (GO:0005216, GO:0005262, GO:0015085, GO:0015278) MODIFY to GO:0005220.
• Transport BP rows (GO:0006811, GO:0006816, GO:0055085, GO:0070588, GO:0051209, GO:0007204) MODIFY to GO:1903514 (ER-specific release; descendant of GO:0051209 verified in OLS).
• GO:0035091 phosphatidylinositol binding MODIFY to GO:0070679 IP3 binding with a source_defects entry (IP3 is soluble, not a PI lipid).
• GO:0005903 brush border (PMID:8288584): abstract says staining is adjacent to the brush border -> MARK_AS_OVER_ANNOTATED plus suspected source defect; apical part of cell kept. Paper is mainly human (HT29 cDNA); species of stained tissue not stated in abstract PMID:8288584.
• Dendrite (PMID:17471556) and neuronal cell body (PMID:17091480) UNDECIDED: abstract-only, abstracts foreground IP3R1 / Schwann cells.
• Nucleoplasm / nucleolus ISO MARK_AS_OVER_ANNOTATED; nucleus ISO MODIFY to nuclear envelope.
• Memory/LTP ISO (mouse phenotype) MARK_AS_OVER_ANNOTATED; taste ISO rows kept non-core (IP3R3 performs the Ca2+-release step in type II taste cells).
• Two bare protein-binding rows removed (policy).
• No NEW rows proposed.