Masp2 (rat) review notes
- 2026-10-28: Fetched Q9JJS8 (MASP2_RAT, RGD:620214, GeneID 64459); 37 GOA rows.
- Literature read: PMID:20118239 and PMID:22167201 (full text), PMID:10913141, 10586086,
15060079, 16272342, 14724269, 12743029, 17204478 (abstracts). See Masp2-deep-research-manual.md.
- Key rat experimental facts: serine protease cleaving C4 and C2 PMID:15060079;
autoactivation PMID:20118239;
homodimer, Ca2+-dependent MBL binding PMID:10913141.
- Decisions: serine-type endopeptidase + lectin pathway core; proteolysis/peptidase/complement
activation/protein maturation refined (MODIFY); cell surface -> symbiont cell surface;
Golgi and cell-surface PRR signaling over-annotated; NEW protein autoprocessing (MASP-2 itself
performs autocatalytic activation cleavage, IDA PMID:15060079).
- Numbering: papers use mature numbering (Ser613, Arg424) = precursor Ser632, Arg443 in Q9JJS8.