GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

InterPro TIR domain (IPR000157) mapping provides evidence for signal transduction function

GO_REF:0000033

Annotation inferences using phylogenetic trees

IBA annotations derived from phylogenetic relationships with characterized Toll receptors
Includes human and mouse TLR orthologs in the reference phylogeny

GO_REF:0000043

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Immunity (KW-0391) and Innate immunity (KW-0399) keywords map to immune process terms

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping

UniProt:Q5TWL7

UniProt entry for TOLL9 (AGAP006974-PA)

Toll-family architecture includes LRRs, a membrane segment at 607–631 and TIR domain at 667–807.

"Belongs to the Toll-like receptor family."

file:ANOGA/TOLL9/TOLL9-deep-research-falcon.md

Deep research report on TOLL9 function

TOLL9 belongs to conserved Toll subfamily with species-specific ectodomain divergence
TIR domain phylogeny supports conserved signaling despite ectodomain variation
Functional pathway inferred from domain architecture and comparative genomics

PMID:38191283

mosGILT controls innate immunity and germ cell development in Anopheles gambiae.

PMID:33963082

Toll9 from Bombyx mori functions as a pattern recognition receptor that shares features with Toll-like receptor 4 from mammals.

PMID:21386906

Lack of an antibacterial response defect in Drosophila Toll-9 mutant.

file:ANOGA/TOLL9/TOLL9-notes.md

TOLL9 re-review with live ontology constraint and exact PAINT lineage

file:ANOGA/TOLL9/TOLL9-ontology-and-lineage.json

TOLL9 ontology constraints and PAINT lineage snapshot