Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro.
PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import.
Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p.
Mitochondrial and peroxisomal targeting of 2-methylacyl-CoA racemase in humans.
The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol.
Identification of PEX5p-related novel peroxisome-targeting signal 1 (PTS1)-binding proteins in mammals.
Domain mapping of human PEX5 reveals functional and structural similarities to Saccharomyces cerevisiae Pex18p and Pex21p.
Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology.
Pex13, the mouse ortholog of the human peroxisome biogenesis disorder PEX13 gene: gene structure, tissue expression, and localization of the protein to peroxisomes.
Functional studies on human Pex7p: subcellular localization and interaction with proteins containing a peroxisome-targeting signal type 2 and other peroxins.
Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay.
PEX5 binds the PTS1 independently of Hsp70 and the peroxin PEX12.
Mammalian Pex14p: membrane topology and characterisation of the Pex14p-Pex14p interaction.
PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins.
Peroxisomal import of human alanine:glyoxylate aminotransferase requires ancillary targeting information remote from its C terminus.
Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export.
Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p.
Comparison of the PTS1- and Rab8b-binding properties of Pex5p and Pex5Rp/TRIP8b.
Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.
Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering.
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
The Peroxisomal Targeting Signal 1 in sterol carrier protein 2 is autonomous and essential for receptor recognition.
PEX14 is required for microtubule-based peroxisome motility in human cells.
PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14.
Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate.
Molecular requirements for peroxisomal targeting of alanine-glyoxylate aminotransferase as an essential determinant in primary hyperoxaluria type 1.
A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes.
Distinct modes of ubiquitination of peroxisome-targeting signal type 1 (PTS1) receptor Pex5p regulate PTS1 protein import.
A proteome-scale map of the human interactome network.
Mechanistic insights into PTS2-mediated peroxisomal protein import: the co-receptor PEX5L drastically increases the interaction strength between the cargo protein and the receptor PEX7.
ATM functions at the peroxisome to induce pexophagy in response to ROS.
The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo.
Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol.
A missense allele of PEX5 is responsible for the defective import of PTS2 cargo proteins into peroxisomes.
Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor.
Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import.
An isoform of pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes.
C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome-targeting signal.
PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11
Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix
PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)
PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11
USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin
PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol
Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6
PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
ATM dimer:PEX5 phosphorylates PEX5
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
NBR1 binds ATM:Ub-p-PEX5:SQSTM1
ATM:PEX5 translocates from cytosol to peroxisomal membrane
ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
SQSTM1 binds ATM dimer:Ub-p-PEX5
USP30 deubiquitinates ATM dimer:Ub-p-PEX5
USP30 binds ATM dimer:Ub-p-PEX5