Annotation inferences using phylogenetic trees

The three literal IBD assertions place outer-arm assembly, alpha-tubulin binding and dynein-heavy-chain binding at PTN000833961 on the human lineage.

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

The UniProt SL-0304 vocabulary entry maps cilium axoneme to GO:0005930.

PMID:15845866

Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients.

Human 190-residue EGFP-DNAL1 associates with DNAH5 in pig tracheal axonemal extract; human testis expression and mouse ciliated-tissue expression were examined separately.

PMID:21496787

Primary ciliary dyskinesia caused by homozygous mutation in DNAL1, encoding dynein light chain 1.

Human N150S DNAL1 is less stable and has impaired heavy-chain/alpha-tubulin association in rat axonemal extracts; affected respiratory cilia have outer-arm defects.

PMID:29601588

ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms.

ZMYND10 associates with and stabilizes DNAI1 in the inspected experimental sections; the DNAL1-specific interaction attributed by the curated record remains unresolved.

PMID:32296183

A reference map of the human binary protein interactome.

A human DNAL1–LRRC40 association is recorded in the HuRI binary interaction screen and its retest records.