Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade.
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Identified and characterized the mammalian 3-ketoacyl-CoA reductase (HSD17B12/KAR) of the microsomal fatty-acid elongation cascade and established its ER localization and NADPH-dependent reduction of 3-ketoacyl-CoA.
"identification and characterization of two mammalian enzymes that catalyze the"
Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women.
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Type 12 17beta-HSD (HSD17B12) efficiently converts estrone (E1) to estradiol (E2) in a heterologous system; residue F234 governs substrate specificity.
"transformation of E1 into E2, thus"
ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.
Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches.
Two modes of regulation of the fatty acid elongase ELOVL6 by the 3-ketoacyl-CoA reductase KAR in the fatty acid elongation cycle.
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KAR (HSD17B12) catalyzes the second step of the fatty-acid elongation cycle, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA using NADPH, and both stimulates and forms a complex with the elongase ELOVL6.
"reduces 3-ketoacyl-CoA to 3-hydroxyacyl-CoA using NADPH as a cofactor"
A proteome-scale map of the human interactome network.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Physical and functional interactome atlas of human receptor tyrosine kinases.
HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA
Synthesis of very long-chain fatty acyl-CoAs