GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

Cadherin/desmocollin domain assignments support calcium binding, membrane association and adhesion; target experiments define their appropriate scope.

GO_REF:0000033

Annotation inferences using phylogenetic trees

The target sequence and descent to literal PAINT ancestral calcium-binding, desmosome and cell-cell adhesion assertions are verified.

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

HPA supports DSC2 plasma-membrane localization in human cell lines and separately records an additional ER observation with uncertain location-specific reliability.

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Mouse Dsc2 transfers are individually assessed against their original experiments, with human corroboration for intestinal adhesion and unresolved source scope for adherens junction and p38 signaling.

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

The current cornified-envelope rule matches the target; the current general-junction rule does not replay, while independent experiments support the biological junction assertion.

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

Combined family, orthology and subcellular-location evidence supports a desmosomal membrane pool.

PMID:17963498

Missense mutations in desmocollin-2 N-terminus, associated with arrhythmogenic right ventricular cardiomyopathy, affect intracellular localization of desmocollin-2 in vitro.

Sequence-verified human DSC2a-GFP localizes at cardiac-cell junctions, while the tested N-terminal disease variants show altered intracellular distribution.

PMID:19056867

Large-scale proteomics and phosphoproteomics of urinary exosomes.

DSC2 was identified in a healthy-human urinary exosome-enriched proteome.

PMID:19199708

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).

The study characterizes a human parotid-saliva exosome-enriched proteome.

PMID:2037591

Desmosomal glycoproteins II and III. Cadherin-like junctional molecules generated by alternative splicing.

Human desmocollin cDNAs encode alternative cytoplasmic tails generated by splicing.

PMID:21062920

Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations.

Human DSC2a and DSC2b tails differ in plaque coupling: both associate with plakophilin-2, while the longer tail supports plakoglobin and desmoplakin-fragment association in the reported assays.

PMID:21220045

A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions.

A DSC2a truncation affects plaque and connexin-43 associations, while DSG2 association is retained in the reported co-immunoprecipitation assay.

PMID:23533145

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

The study characterizes exosome-enriched expressed-prostatic-secretion urine samples from human cancer and noncancer groups.

PMID:23863954

Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population.

A human DSC2 truncation is associated with severe cardiomyopathy and altered cardiac-junction protein localization.

PMID:26763450

Desmoglein 3-Dependent Signaling Regulates Keratinocyte Migration and Wound Healing.

Dsg3 perturbation regulates keratinocyte migration and p38MAPK-associated signaling in the reported systems.

PMID:27298358

Structural basis of adhesive binding by desmocollins and desmogleins.

Purified human desmosomal cadherin ectodomains form adhesive desmoglein–desmocollin interactions; DSC2 self-association is much weaker in these bulk assays.

PMID:31967937

Desmocollin-2 promotes intestinal mucosal repair by controlling integrin-dependent cell adhesion and migration.

DSC2 supports intestinal epithelial migration, traction and mucosal repair in human-cell and mouse experiments.

PMID:33596089

Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2.

DSC2 supports epithelial adhesion and timely recruitment of DSG2 during junction reassembly.

PMID:35922511

A physical wiring diagram for the human immune system.

The human ectodomain library and interaction network include DSC2–DSG2, with the tabulated affinity explicitly attributed to the earlier 2016 study.

Reactome:R-HSA-6809393

Keratin filaments bind cell-cell adhesion complexes

The event includes DSC2 in a desmosome/desmocollin structural component of the modeled membrane network.

Reactome:R-HSA-6810357

Fillagrin and keratin intermediate filaments polymerize forming a network

The event includes DSC2 in a desmosome/desmocollin structural component of the modeled membrane network.

Reactome:R-HSA-6810937

Lamellar bodies bind the early cornified envelope

The event includes DSC2 in a desmosome/desmocollin structural component of the modeled membrane network.

Reactome:R-HSA-6811539

Reinforcement of the Cornified Envelope

The event includes DSC2 in a desmosome/desmocollin structural component of the modeled membrane network.

Reactome:R-HSA-6814298

Late envelope proteins bind cornified envelope:CDSN

The event includes DSC2 in a desmosome/desmocollin structural component of the modeled membrane network.

Reactome:R-HSA-6814387

CASP14 cleaves filaggrin

The event includes DSC2 in a desmosome/desmocollin structural component of the modeled membrane network.

Reactome:R-HSA-6814695

PERP binds desmosomes

The event includes DSC2 in a desmosome/desmocollin structural component of the modeled membrane network.

Reactome:R-HSA-6814734

CDSN binds the cornified envelope

The event includes DSC2 in a desmosome/desmocollin structural component of the modeled membrane network.

Reactome:R-HSA-6814764

Plasma membrane resorption

The event includes DSC2 in a desmosome/desmocollin structural component of the modeled membrane network.

Reactome:R-HSA-8942224

Filaggrin binds Keratin tonofilament:Desmosome

The event includes DSC2 in a desmosome/desmocollin structural component of the modeled membrane network.

PMID:24610950

Different roles of cadherins in the assembly and structural integrity of the desmosome complex.

Single-molecule experiments detect calcium-dependent DSC2 self-binding and link extracellular contacts to desmosome-punctum recruitment.

PMID:29999492

E-cadherin binds to desmoglein to facilitate desmosome assembly.

Single-molecule experiments detect both DSC2 self-binding and DSC2–DSG2 heterophilic binding with different calcium and kinetic behavior.

PMID:15775979

E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions.

Conditional mouse epidermal E-cadherin loss alters junctional organization while desmosomal structures persist.

PMID:22171007

Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca²+-free interdomain linkers.

Drosophila N-cadherin ectodomain structures show calcium-containing and calcium-free interdomain interfaces.

PMID:15081105

The lanceolate hair rat phenotype results from a missense mutation in a calcium coordinating site of the desmoglein 4 gene.

A rat desmoglein-4 calcium-site mutation affects the extracellular cadherin region and hair-follicle biology.

https://www.proteinatlas.org/ENSG00000134755-DSC2/subcellular

Subcellular - DSC2 - The Human Protein Atlas

HPA supports DSC2 plasma-membrane localization in human cell lines and separately records an additional ER observation with uncertain location-specific reliability.

PMID:16917092

Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy.