Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
Towards a proteome-scale map of the human protein-protein interaction network.
Interaction between glycogenin and glycogen synthase.
Defining the membrane proteome of NK cells.
Glycogenin-1 deficiency and inactivated priming of glycogen synthesis.
Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
A proteome-scale map of the human interactome network.
Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate.
UniProtKB entry P46976 (GLYG_HUMAN), Glycogenin-1
GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1
Autoglucosylation of GYG1 complexed with GYS1-b
GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a
Autoglucosylation of GYG1 complexed with GYS1-a
Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1
GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b
EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex
NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1
EPM2A dimer dephosphorylates phosphoglycogen-GYG1
PPP1R3C binds to glycogen:GYG1:GYS1
GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1
Defective EPM2A does not dephosphorylate phosphoglycogen (type 2A disease)
Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease)
Defective GYG1 is not autoglucosyolated
Defective GYS1 does not transfer glucose to growing glycogen chains
Exocytosis of secretory granule lumen proteins
Exocytosis of ficolin-rich granule lumen proteins
limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose
GAA hydrolyzes lysosomal glycogen
Defective GAA does not hydrolyze lysosomal glycogen