Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis.
Platelet-derived growth factor receptor beta regulates migration and DNA synthesis in metanephric mesenchymal cells.
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.
Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF beta-receptor null mice.
Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor.
Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells.
Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell.
Crystal structure of human platelet-derived growth factor BB.
Hypoxia regulates PDGF-B interactions between glomerular capillary endothelial and mesangial cells.
Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells.
c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-induced DNA synthesis in mesangial cells.
Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation.
Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB.
Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cells.
Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels.
TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis in different cell types: involvement of Src and PLC.
PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA.
Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype.
Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts.
Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex.
Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells.
Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation.
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.
MicroRNA-638 is highly expressed in human vascular smooth muscle cells and inhibits PDGF-BB-induced cell proliferation and migration through targeting orphan nuclear receptor NOR1.
SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis.
PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication.
miR-18a-5p MicroRNA Increases Vascular Smooth Muscle Cell Differentiation by Downregulating Syndecan4.
Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes.
Collagen-induced binding to human platelets of platelet-derived growth factor leading to inhibition of P43 and P20 phosphorylation.
miRNA-34a reduces neointima formation through inhibiting smooth muscle cell proliferation and migration.
A common PDGF receptor is activated by homodimeric A and B forms of PDGF.
Platelet-derived growth factor: purification and partial characterization.
A reference map of the human binary protein interactome.
Platelet-derived growth factor: identification of constituent polypeptide chains.
Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor.
Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB).
Platelet-derived growth factor beta-receptors can both promote and inhibit chemotaxis in human vascular smooth muscle cells.
Apolipoprotein E inhibits platelet-derived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase.
Activated PLC gamma dissociates from the PDGF receptor
Phosphorylation of PLCgamma by PDGFR
PLC-gamma binds to the active receptor
PDGF dimer binds two receptors simultaneously
SHP2 binds to the active receptor
PI3-kinase binds to the active receptor
Autophosphorylation of PDGF beta receptors
GAP binds to PDGF-beta receptors only
PI3K catalyses the phosphorylation of PIP2 to PIP3
SH2 domain of Src binds to the active receptor
GRB2:SOS1 complex binds to the active receptor
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
PI3K phosphorylates PIP2 to PIP3
HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer
PI3K inhibitors block PI3K catalytic activity
STAT binds to the active receptor
p130Cas and C3G bind PDGFR bound Crk
Translocation of PDGF from ER to Golgi
PDGF binds to extracellular matrix proteins
Grb7 binds to the active PDGF receptor
Crk binds to the active PDGF receptor
Nck binds to the active PDGF receptor
Autophosphorylation of PDGF alpha receptors
Autophosphorylation of PDGF alpha/beta receptors
Exocytosis of platelet alpha granule contents
RAS GEFs promote RAS nucleotide exchange
PTPN12 dephosphorylates PDGFRB at Y1021
Falcon deep research report on PDGFB
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PDGFB is a secreted PDGF ligand whose core GO-relevant evidence is receptor binding, growth factor activity, dimerization, extracellular localization, and ligand-attributable vascular/mural-cell processes.
"This report summarizes **GO-relevant evidence for PDGFB as a secreted PDGF ligand**: disulfide-linked dimer formation (PDGF‑BB; PDGF‑AB), **direct binding/activation of PDGF receptor dimers (PDGFRA/PDGFRB)**, secretion/localization (extracellular space; ER/Golgi processing; ECM/HS retention), platelet α‑granule localization (only where explicitly stated), and **ligand-attributable biological processes** (pericyte recruitment/coverage; angiogenesis/blood vessel morphogenesis; limited wound-healing evidence). It **excludes** receptor **intrinsic kinase activity** (peptidyl-tyrosine phosphorylation), downstream pathway terms (PI3K–AKT, ERK/MAPK, ROS/NADPH oxidase), and broad transcriptional/miRNA effects unless strictly necessary to interpret ligand localization or binding (ostman1992pdgfaaandpdgfbb pages 1-2, fredriksson2004thepdgffamily pages 5-7)."
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PDGFB should not be annotated with receptor tyrosine kinase activity or generic downstream PI3K/AKT, ERK/MAPK, ROS, or transcriptional outputs as core functions.
"Do **not** annotate PDGFB with receptor enzymatic activities (e.g., **protein tyrosine kinase activity**, **peptidyl-tyrosine phosphorylation**) or generic downstream pathways (PI3K/AKT, ERK/MAPK, ROS) based solely on PDGFR signaling descriptions; these belong to PDGF receptors or downstream effectors, not the PDGFB ligand itself (fredriksson2004thepdgffamily pages 5-7, strell2024functionalandclinical pages 3-5)."
UniProtKB P01127 record for PDGFB