Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
The putative chaperone calmegin is required for sperm fertility.
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Calmegin is a testis-specific ER membrane protein homologous to calnexin that binds nascent polypeptides during spermatogenesis; Clgn-null male mice are nearly sterile because their sperm fail to adhere to the egg zona pellucida.
"Calmegin is a testis-specific ER protein that is homologous to calnexin. Here we show that calmegin binds to nascent polypeptides during spermatogenesis... Homozygous-null male mice are nearly sterile even though spermatogenesis is morphologically normal and mating is normal. In vitro, sperm from homozygous-null males do not adhere to the egg extracellular matrix (zona pellucida)"
A developmentally regulated chaperone complex for the endoplasmic reticulum of male haploid germ cells.
Cloning and characterization of the human Calmegin gene encoding putative testis-specific chaperone.