GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000108

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

file:RAMVA/RvY_13070/RvY_13070-bioinformatics/RESULTS.md

Bioinformatics analysis of Cu/Zn SOD paralogs in R. varieornatus

Bioinformatic verdict for RvY_03757: PROBABLY IMPAIRED. 193 aa (172 mature); all 4 Cu His preserved by sequence but PROSITE PS00087 fails

PMID:37358501

Structure of a superoxide dismutase from a tardigrade: Ramazzottius varieornatus strain YOKOZUNA-1.

Crystal structures of RvSOD15 (PDB 7ypp WT, 7ypr V87H mutant) show an atypical T-shaped Cu site with only three histidines; V87H rescue does not restore canonical activity, supporting paralog-specific catalytic divergence among R. varieornatus Cu/Zn SODs.

PMID:39125965

Antioxidant Defense in the Toughest Animals on the Earth: Its Contribution to the Extreme Resistance of Tardigrades.

This 2024 review summarizes the expanded R. varieornatus SOD repertoire and highlights that some tardigrade Cu/Zn SOD paralogs are atypical and may have reduced or lost canonical SOD activity, supporting cautious annotation of RvY_03757 without direct biochemical evidence.

file:RAMVA/RvY_03757/RvY_03757-deep-research-falcon.md

Deep research report on RvY_03757 (Falcon/Edison Scientific Literature)

No primary publication directly characterizes RvY_03757; the combined evidence from Cu/Zn SOD family biochemistry, the closely related RvSOD15 structure (Sim 2023), and the 2024 tardigrade antioxidant defense review (Sadowska-Bartosz 2024) supports a "Cu/Zn SOD-like protein with uncertain catalytic activity" annotation, consistent with the existing bioinformatic verdict that PROSITE PS00087 fails despite preserved Cu histidines.