Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
A novel ubiquitin ligase is deficient in Fanconi anemia.
UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation.
UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination.
Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI.
FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL.
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.
A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.
FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway.
Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection.
The Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCL.
A proteome-scale map of the human interactome network.
A reference map of the human binary protein interactome.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
FA core complex assembles at DNA interstrand crosslinks (ICLs)
FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex
Monoubiquitination of FANCD2:FANCI
DNA nucleases bind monoubiquitinated ID2 complex
DNA nucleases unhook the interstrand crosslink (ICL)
Translesion synthesis across unhooked ICL by POLN
FANCD2 deubiquitination by USP1:WDR48
The complex of ATR and ATRIP is recruited to ICL-DNA
ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA
FA core complex:HSP70s binds PKR
A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.