Gene Ontology annotation through association of InterPro records with GO terms
Use of the ND evidence code for Gene Ontology (GO) terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Comparison of molecular mechanisms mediating cell contact phenomena in model developmental systems: an exploration of universality.
Exposure of cells to a cell number-counting factor decreases the activity of glucose-6-phosphatase to decrease intracellular glucose levels in Dictyostelium discoideum.
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Counting factor signal transduction inhibits glucose-6-phosphatase to decrease intracellular glucose and regulate group size, the downstream metabolic arm of the pathway that SmlA modulates.
"part of the CF signal transduction pathway involves inhibiting the activity of glucose-6-phosphatase, decreasing intracellular glucose levels and affecting the levels of other metabolites, to regulate group size"
A protein in crude cytosol regulates glucose-6-phosphatase activity in crude microsomes to regulate group size in Dictyostelium.
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A counting-factor-regulated cytosolic protein activity modulates microsome-associated glucose-6-phosphatase to regulate group size; smlA-null cells are used as a high-CF background in these assays.
"CF regulates one or more proteins greater than 10 KDa in crude cytosol that affect microsome-associated glucose-6-phosphatase activity"
A cell number-counting factor regulates levels of a novel protein, SslA, as part of a group size regulation mechanism in Dictyostelium.
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smlA-null cells form small groups because they oversecrete counting factor; SslA was isolated as a second-site suppressor, placing SmlA in the counting-factor group-size pathway.
"a transformant that forms small groups due to oversecretion of CF"
Global transcriptional responses to cisplatin in Dictyostelium discoideum identify potential drug targets.
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smlA mutation alters cisplatin sensitivity in a drug-target screen, while the paper attributes SmlA's characterized function to aggregate size regulation.
"smlA participate in aggregate size regulation"
Proteomic analysis of Legionella-containing phagosomes isolated from Dictyostelium.
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SmlA appears in a large-scale phagosome proteome (157 proteins), an incidental detection inconsistent with its cytosolic localization.
"identified 157 phagosome host proteins"
A Dictystelium mutant with defective aggregate size determination.
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SmlA is a cytosolic protein present in vegetative and early developing cells.
"SmlA is a 35x10(3) Mr cytosolic protein present in all vegetative and developing cells"
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SmlA regulates the secretion or processing of a secreted factor that controls aggregate size.
"the cytosolic protein SmlA regulates the secretion or processing of a secreted factor that regulates aggregate size"
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SmlA itself is not detectably secreted.
"Although there is no detectable SmlA protein secreted from cells"
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SmlA has no significant sequence similarity to known proteins, consistent with an undetermined molecular function.
"The sequence of the cDNA and the derived amino acid sequence of the SmlA protein show no significant similarity to any known sequence."