Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods.
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.
FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis.
Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington's disease.
Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.
Huntingtin contains a highly conserved nuclear export signal.
Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1.
SUMO modification of Huntingtin and Huntington's disease pathology.
A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins.
Polyglutamine expansion of huntingtin impairs its nuclear export.
Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis.
Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.
A human protein-protein interaction network: a resource for annotating the proteome.
Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease.
Structural insights into the specific binding of huntingtin proline-rich region with the SH3 and WW domains.
Huntingtin interacting proteins are genetic modifiers of neurodegeneration.
Huntingtin facilitates dynein/dynactin-mediated vesicle transport.
Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity.
HYPK, a Huntingtin interacting protein, reduces aggregates and apoptosis induced by N-terminal Huntingtin with 40 glutamines in Neuro2a cells and exhibits chaperone-like activity.
Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease.
Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation.
Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons.
Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued.
Huntingtin promotes cell survival by preventing Pak2 cleavage.
Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity.
Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity.
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy.
pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking.
Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis.
Dictyostelium huntingtin controls chemotaxis and cytokinesis through the regulation of myosin II phosphorylation.
Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease.
Intrinsically disordered proteins as molecular shields.
Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease.
α-Synuclein modifies huntingtin aggregation in living cells.
Replacement of charged and polar residues in the coiled-coiled interface of huntingtin-interacting protein 1 (HIP1) causes aggregation and cell death.
SERF protein is a direct modifier of amyloid fiber assembly.
Development and application of a DNA microarray-based yeast two-hybrid system.
Chaperone-like activity of high-mobility group box 1 protein and its role in reducing the formation of polyglutamine aggregates.
The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.
Huntingtin functions as a scaffold for selective macroautophagy.
siRNA screen identifies QPCT as a druggable target for Huntington's disease.
Quantitative interaction proteomics of neurodegenerative disease proteins.
Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-Acyltransferases.
Human mutant huntingtin disrupts vocal learning in transgenic songbirds.
ENC1 Modulates the Aggregation and Neurotoxicity of Mutant Huntingtin Through p62 Under ER Stress.
Polyglutamine tracts regulate beclin 1-dependent autophagy.
Architecture of the human interactome defines protein communities and disease networks.
The cryo-electron microscopy structure of huntingtin.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Global Proximity Interactome of the Human Macroautophagy Pathway.
Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins.
A huntingtin-associated protein enriched in brain with implications for pathology.
Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons.
Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain.
A human HAP1 homologue. Cloning, expression, and interaction with huntingtin.
Association of HAP1 isoforms with a unique cytoplasmic structure.
Deep research (falcon) on HTT function
Deep research (openai) on HTT function