Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans.
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SEK-1 is required for asymmetric expression of str-2 in AWC neurons
"SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans."
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SEK-1 functions downstream of UNC-43 (CaMKII) and NSY-1 (MAPKKK)
"SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans."
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SEK-1 interacts with NSY-1
"SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans."
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Demonstrates dual-specificity kinase activity
"SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans."
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Activated by phosphorylation at Ser-204 and Thr-208
"SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans."
A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity.
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sek-1 identified in screen for enhanced susceptibility to P. aeruginosa
"A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity."
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nsy-1/sek-1/pmk-1 form conserved p38 MAPK pathway for pathogen defense
"A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity."
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sek-1 mutants hypersensitive to bacterial pathogens
"A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity."
Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins.
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p38 MAPK pathway required for defense against Cry5B toxin
"Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins."
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sek-1 transcriptionally upregulated by Cry5B
"Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins."
The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response.
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p38 pathway regulates SKN-1 nuclear localization during oxidative stress
"The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response."
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gcs-1 expression requires p38 pathway
"The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response."
Caenorhabditis elegans pgp-5 is involved in resistance to bacterial infection and heavy metal and its regulation requires TIR-1 and a p38 map kinase cascade.
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pgp-5 induction requires TIR-1 and p38 cascade including SEK-1
"Caenorhabditis elegans pgp-5 is involved in resistance to bacterial infection and heavy metal and its regulation requires TIR-1 and a p38 map kinase cascade."
Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity.
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Conditioning protection requires p38 MAP kinase pathway
"Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity."
The Caenorhabditis elegans Ste20-related kinase and Rac-type small GTPase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress response.
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Context for MAPK signaling in stress response
"The Caenorhabditis elegans Ste20-related kinase and Rac-type small GTPase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress response."
Global functional analyses of cellular responses to pore-forming toxins.
Dysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegans.
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sek-1 mutants show enhanced sensitivity to 6-OHDA neurotoxicity
"Dysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegans."
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sek-1 functions in same pathway as lrk-1 and pmk-1
"Dysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegans."
Stabilization of RNT-1 protein, runt-related transcription factor (RUNX) protein homolog of Caenorhabditis elegans, by oxidative stress through mitogen-activated protein kinase pathway.
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RNT-1 phosphorylated by SEK-1/PMK-1 in vitro
"Stabilization of RNT-1 protein, runt-related transcription factor (RUNX) protein homolog of Caenorhabditis elegans, by oxidative stress through mitogen-activated protein kinase pathway."
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MAP kinase pathway required for RNT-1 stabilization during oxidative stress
"Stabilization of RNT-1 protein, runt-related transcription factor (RUNX) protein homolog of Caenorhabditis elegans, by oxidative stress through mitogen-activated protein kinase pathway."
The pseudokinase NIPI-4 is a novel regulator of antimicrobial peptide gene expression.
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SEK-1 part of MAPK cassette for nlp-29 induction
"The pseudokinase NIPI-4 is a novel regulator of antimicrobial peptide gene expression."
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Required for antimicrobial peptide expression after fungal infection
"The pseudokinase NIPI-4 is a novel regulator of antimicrobial peptide gene expression."
Orthosiphon stamineus protects Caenorhabditis elegans against Staphylococcus aureus infection through immunomodulation.
Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection.
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UPRmt pre-activation enhances survival of sek-1 mutants during P. aeruginosa infection
"Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection."
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UPRmt can function independently of NSY-1/SEK-1/PMK-1 pathway
"Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection."
Deep research report on sek-1