Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic Gene Ontology annotation based on Rhea mapping

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

TGF-beta activates ERK5 in human renal epithelial cells.

Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4).

Next-generation sequencing to generate interactome datasets.

Toward an understanding of the protein interaction network of the human liver.

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.

Architecture of the human interactome defines protein communities and disease networks.

An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).

A reference map of the human binary protein interactome.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Components of a new human protein kinase signal transduction pathway.

PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway.

Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway.

Structural mechanism for the specific assembly and activation of the extracellular signal regulated kinase 5 (ERK5) module.

Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2.

A novel mitogen-activated protein kinase docking site in the N terminus of MEK5alpha organizes the components of the extracellular signal-regulated kinase 5 signaling pathway.

Differential role of MEK5alpha and MEK5beta in BMK1/ERK5 activation.

Isolation of MEK5 and differential expression of alternatively spliced forms.

BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C.

MEK5/ERK5 pathway: the first fifteen years.

Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor.

Hypertrophic responses to cardiotrophin-1 are not mediated by STAT3, but via a MEK5-ERK5 pathway in cultured cardiomyocytes.

Activation of the MEK5/ERK5 cascade is responsible for biliary dysgenesis in a rat model of Caroli's disease.

MEK5 and ERK5 are mediators of the pro-myogenic actions of IGF-2.

Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells.

UniProtKB entry Q13163 (MP2K5_HUMAN)

Deep research report on human MAP2K5 (falcon)