Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Deep research summary for Bacteriophage T4 ndd
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Ndd is an early T4 infection effector that causes rapid host nucleoid disruption and redistribution toward the cell periphery within 2 to 3 minutes after infection.
"The best-supported functional annotation for T4 Ndd is that it is an **early infection effector** that causes rapid **host nucleoid disruption/redistribution**, a hallmark phenotype beginning **~2–3 minutes** after infection"
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Expression of T4 Ndd in Escherichia coli disrupts the nucleoid and relocalizes chromosomal DNA toward the inner membrane periphery.
"short-term expression of bacteriophage T4 **Ndd** disrupted the nucleoid and relocalized it toward the **inner membrane/periphery**"
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Ndd binds double-stranded DNA but not single-stranded DNA and inhibits host replication without cleaving DNA.
"function as a **structural bridge** between DNA and membrane"
UniProtKB entry P15556 (NDD_BPT4)
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Ndd disorganizes the host nucleoid, inhibits host DNA replication without DNA cleavage, and binds dsDNA but not ssDNA.
"Disorganizes the host nucleoid and inhibits replication, but without host DNA cleavage or degradation. Only the architecture of the nucleoid is affected. May act on the host chromosomal sequences that determine the structure of the nucleoid. Binds to dsDNA but not to ssDNA. {ECO:0000269|PubMed:9748458}."