Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs

Combined Automated Annotation using Multiple IEA Methods

Pax genes and their role in organogenesis.

Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development.

Pax4 represses pancreatic glucagon gene expression.

Opposing actions of Arx and Pax4 in endocrine pancreas development.

The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation.

Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development.

The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas.

The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells.

The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice.

The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas.

Developmental and daily expression of the Pax4 and Pax6 homeobox genes in the rat retina: localization of Pax4 in photoreceptor cells.

Developmental and diurnal dynamics of Pax4 expression in the mammalian pineal gland: nocturnal down-regulation is mediated by adrenergic-cyclic adenosine 3',5'-monophosphate signaling.

The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells.

Inhibitory effect of pax4 on the human insulin and islet amyloid polypeptide (IAPP) promoters.

Evolution of the vertebrate Pax4/6 class of genes with focus on its novel member, the Pax10 gene.

Complete loss of PAX4 causes transient neonatal diabetes in humans.

PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic Islet.

DNA binding and transactivating properties of the paired and homeobox protein Pax4.

Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation.

Molecular cloning of mouse paired-box-containing gene (Pax)-4 from an islet beta cell line and deduced sequence of human Pax-4.

Pax4 acts as a key player in pancreas development and plasticity.

mouse/Pax4/Pax4-uniprot.txt

mouse/Pax4/Pax4-deep-research-claude-code.md

mouse/Pax4/Pax4-bioinformatics/RESULTS.md

mouse/Pax4/Pax4-bioinformatics/panther_tree_paths.md