Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Semaphorin controls epidermal morphogenesis by stimulating mRNA translation via eIF2alpha in Caenorhabditis elegans.
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Semaphorin/plexin signaling lowers eIF2alpha phosphorylation to permit translation needed for epidermal morphogenesis; S49 phosphomimetic and non-phosphorylatable transgenes modulate the phenotype.
"In semaphorin/plexin mutants, a marked elevation in the phosphorylation of eIF2alpha is observed, which causes translation repression and is causally related to the morphological epidermal phenotype in the mutants."
Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2.
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GCN-2 phosphorylates eIF2alpha in response to mitochondrial stress.
"A similar result was observed in the isp-1(qm150) mutant, supporting the role of GCN-2 in eIF2α phosphorylation in response to stress"
Molecular Determinants of the Regulation of Development and Metabolism by Neuronal eIF2α Phosphorylation in Caenorhabditis elegans.
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Phosphomimetic eIF2alpha(S49D) in ASI neurons enhances dauer entry.
"Furthermore, we show that constitutive expression of eIF2α carrying a phosphomimetic S49D mutation in the ASI neurons enhances dauer entry through bypassing the requirement for nutritionally deficient conditions."
Loss of eif-2alpha phosphorylation on S49 (mammalian S51) associated with the integrated stress response hastens development in C. elegans.
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Ser49 is the stress-induced phosphorylation site; S49A mutants are viable and develop faster.
"This result confirms that serine 49 is the site of phosphorylation in eif-2alpha in response to salt stress and is a novel finding for heat and oxidative stress in C. elegans."
The integrated stress response protects against ER stress but is not required for altered translation and lifespan from dietary restriction in Caenorhabditis elegans.
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eIF2alpha Ser49 phosphorylation is required for translational repression and survival under ER stress, but not for dietary-restriction effects on translation or lifespan.
"The ISR was not dispensable under ER stress conditions, as demonstrated by the requirement for PERK and eIF2α phosphorylation for decreased translation and wild type-like survival."