DDP1 (YOR163W, Q99321) notes

• Nudix (MutT) hydrolase; (di)adenosine polyphosphate hydrolase, Ap6A preferred PMID:10085096.
• Also hydrolyses inositol pyrophosphates (DIPP activity) PMID:10419486; [UniProt:Q99321 "cleaves a beta-phosphate from the diphosphate groups in PP-InsP5"].
• Endopolyphosphatase PMID:21775424; PMID:31175919.
• In vitro mRNA decapping PMID:23353937 - non-core.
• Localization cytoplasm + nucleus (GFP) [UniProt:Q99321 "SUBCELLULAR LOCATION: Cytoplasm ... Nucleus"].

Curation decisions

• YeastPathways RCA "inositol phosphate biosynthetic process" is superpathway inheritance for a catabolic (PP-InsP -> InsP) enzyme: MODIFY to GO:0071544 diphosphoinositol polyphosphate catabolic process.
• Core MF: GO:0008486 (PP-InsP phosphatase) + GO:0034431 (Ap6A hydrolase). PolyP catabolism kept non-core (Ppn1/Ppn2/Ppx1 dominant).