Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function.
RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes.
The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
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Crystal structure of CSL-NICD(ANK)-MAML1 on DNA.
"We report here the crystal structure of a Notch transcriptional activation complex containing the ankyrin domain of human Notch1 (ANK), the transcription factor CSL on cognate DNA, and a polypeptide from the coactivator Mastermind-like-1 (MAML-1)."
A metabolic enzyme of the short-chain dehydrogenase/reductase superfamily may moonlight in the nucleus as a repressor of promoter activity.
Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription.
Slug is a direct Notch target required for initiation of cardiac cushion cellularization.
Direct inhibition of the NOTCH transcription factor complex.
Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.
RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J.
Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis.
Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway.
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.
NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.
Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2.
Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity.
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.
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RBPJ recruits L3MBTL3-KDM1A for repression.
"In the absence of NOTCH ICD, RBPJ recruits L3MBTL3 and the histone demethylase KDM1A (also known as LSD1) to the enhancers of Notch target genes, leading to H3K4me2 demethylation and to transcriptional repression."
Pharmacological disruption of the Notch transcription factor complex.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Pathogenic variants in KCTD1 disrupt cAMP signaling and cellular communication associated with developmental pathways.
The amino-terminal domains of Epstein-Barr virus nuclear proteins 3A, 3B, and 3C interact with RBPJ(kappa).
CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex.
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CBF1/RBPJ binds corepressor CIR which links it to HDAC complexes.
"We have examined the mechanism of CBF1-mediated repression and show that CBF1 binds to a unique corepressor, CBF1 interacting corepressor (CIR)."
NICD1 in complex with RBPJ (CSL) recruits MAML
Formation of CSL-NICD coactivator complex
NICD2 binds RBPJ and MAML in the nucleus
NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC
NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML
CDK8 phosphorylates NICD1 PEST domain mutants
NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL)
NOTCH2 coactivator complex binds FCER2 promoter
Formation of CSL NCOR corepressor complex
NOTCH1 Coactivator Complex binds MYC promoter
NOTCH1 Coactivator Complex binds HES5 promoter
NOTCH1 PEST domain mutants bind HES1 promoter
NOTCH1 PEST domain mutants bind MYC promoter
NOTCH1 PEST domain mutants bind HES5 promoter
NOTCH1 PEST domain mutants bind promoters of HEY genes
RUNX3 binds the NOTCH1 coactivator complex
RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter
NOTCH1 coactivator complex binds NOTCH3 gene
NOTCH3 coactivator complex binds DLGAP5 gene promoter
NOTCH3 coactivator complex binds PBX1 gene promoter
NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter
NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter
NICD1 displaces NCOR co-repressor complex from CSL
MAML recruits CDK8:CCNC to xNICD1
CDK8 phosphorylates xNICD1
mNICD1 Chimeric Enhancer Complex binds Hes1 promoter
NICD3 binds RBPJ and MAML in the nucleus
Notch3 coactivator complex binds Hes1 gene promoter
NICD4 binds RBPJ and MAML in the nucleus
Notch4 binds FLT4 gene promoter
Falcon deep research report on human RBPJ
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RBPJ switches between repression and activation depending on Notch signaling.
"The hallmark feature of RBPJ is its ability to function as a **molecular switch** between transcriptional repression and activation, depending on the presence of Notch signaling"
UniProtKB entry Q06330 (SUHH_HUMAN / RBPJ)