Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells.
TIP120A associates with cullins and modulates ubiquitin ligase activity.
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.
RhoBTB2 is a substrate of the mammalian Cul3 ubiquitin ligase complex.
BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.
Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.
A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells.
Regulation of TIP60 by ATF2 modulates ATM activation.
KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases.
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.
SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.
Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Control of rapsyn stability by the CUL-3-containing E3 ligase complex.
The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells.
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling.
Defining the human deubiquitinating enzyme interaction landscape.
The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes.
Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement.
Defining the membrane proteome of NK cells.
The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.
The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses.
Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy.
Network organization of the human autophagy system.
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.
Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1.
COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.
Ubiquitin ligase activity of Cul3-KLHL7 protein is attenuated by autosomal dominant retinitis pigmentosa causative mutation.
Toward an understanding of the protein interaction network of the human liver.
Ubiquitin-dependent regulation of COPII coat size and function.
NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway.
KBTBD13 interacts with Cullin 3 to form a functional ubiquitin ligase.
Translational homeostasis via the mRNA cap-binding protein, eIF4E.
Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase.
A homozygous mutation in KCTD7 links neuronal ceroid lipofuscinosis to the ubiquitin-proteasome system.
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates Aurora-A.
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.
Ubiquitylation-dependent localization of PLK1 in mitosis.
CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling.
Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.
Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation.
Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification.
Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression.
Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localization.
K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking.
Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3.
Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension.
KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development.
A proteome-scale map of the human interactome network.
A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations.
KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination.
CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.
Structural Insights into KCTD Protein Assembly and Cullin3 Recognition.
Cell-fate determination by ubiquitin-dependent regulation of translation.
Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.
Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.
The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states.
Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection.
Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.
Armc5 deletion causes developmental defects and compromises T-cell immune responses.
Defining the human sperm microtubulome: an integrated genomics approach.
Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation.
Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila.
KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.
Dimerization quality control ensures neuronal development and survival.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1.
CRL3s: The BTB-CUL3-RING E3 Ubiquitin Ligases.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.
ARMC5-CUL3 E3 ligase targets full-length SREBF in adrenocortical tumors.
XAF1 prevents hyperproduction of type I interferon upon viral infection by targeting IRF7.
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.
The Role of PIK3R1 in Metabolic Function and Insulin Sensitivity.
Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme.
Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation.
ARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans.
Redundant pathways for removal of defective RNA polymerase II complexes at a promoter-proximal pause checkpoint.
CRL3(ARMC5) ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription.
Multimodal cell maps as a foundation for structural and functional genomics.
cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.
Cloning and expression analysis of a novel salicylate suppressible gene, Hs-CUL-3, a member of cullin/Cdc53 family.
DVL is ubiquitinated by CUL3:KLHL12:RBX1
Ubiquitinated DVL is degraded by the proteasome
DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex
GLI2,3 are degraded by the proteasome
phosphorylated GLI proteins bind SPOP:CUL3:RBX1
SPOP:CUL3:RBX1 ubiquitinates GLI2,3
KBTBD7:CUL3:RBX1 ubiquitinates NF1
NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex
CAND1 binds cytosolic CRL E3 ubiquitin ligases
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
RHOBTB1 binds interacting proteins at the endosome membrane
RHOBTB2 binds interacting proteins at the endosome membrane
RHOBTB3 binds interacting proteins at trans-Golgi network
NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer
CUL3:RBX1 ubiquitinates KEAP1
RBX1:CUL3 dissociates from forming autophagosome
MAP1LC3B binds KEAP1 and SQSTM1
SESN1,SESN1 bind SQSTM1 and KEAP1
SPOP:CUL3:RBX1 binds to CD274
SPOP-mediated degradation of CD274 by 26S Proteosome
CD274 ubiquitination by SPOP:CUL3:RBX1 complex
Falcon deep research report on CUL3