Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of intracellular localizations of expressed fusion proteins in living cells
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity.
Purification and characterization of the human gamma-secretase complex.
Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch.
Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Cleavage of ERBB4m80 by gamma-scretase complex
gamma-secretase cleaves the p75NTR transmembrane domain
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6
NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants
gamma-secretase cleaves EPHB2
Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)
NEXT3 is cleaved to produce NICD3
Gamma-secretase cleaves YBX1:NOTCH3
TGFBR3(784-851) degradation
Gamma-secretase complex cleaves mNEXT2
Gamma-secretase cleaves Notch4