Gene Ontology annotation through association of InterPro records with GO terms.
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic assertion according to rules Marks annotations derived from UniProtKB/Swiss-Prot entries that are annotated with the UniRule system.
Combined automated annotation using Multiple Evidence Codes.
UniProtKB record for P06808 (HOLIN_BPT4)
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Holin T accumulates in the host inner membrane and forms micron-scale pores that allow endolysin escape into the periplasm for host cell lysis, while its activity is inhibited by antiholin RI during lysis inhibition.
"Accumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of micron-scale pores (holes) causing host cell membrane disruption and endolysin escape into the periplasmic space (PubMed:11255004)."
Deep research summary for Enterobacteria phage T4 holin T (gene t / rV)
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Holin T is a 218-amino-acid single-pass type II inner-membrane protein that acts as the lysis timer and pore-forming component of the T4 lysis cassette.
"Gene **t** (synonym **rV**) of *Enterobacteria phage T4* encodes **holin T**, a 218-aa bitopic (single-pass) inner-membrane protein that acts as the **lysis timer/trigger** for phage release."