Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis.
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A quantitative petite-frequency screen identified ~100 previously uncharacterized proteins (the AIM series) whose deletion alters mitochondrial biogenesis/inheritance in S. cerevisiae; AIM6/YDL237W was named and scored in this study (per-gene data in the paper's Table S2).
"we have identified 100 proteins whose deficiency alters mitochondrial biogenesis and inheritance in Saccharomyces cerevisiae"
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The authors caution that such deletion phenotypes need not reflect a direct intramitochondrial molecular role, since non-mitochondrial proteins can regulate biogenesis and some mutants may affect biogenesis indirectly.
"raise the possibility that these mutants are somehow indirectly affecting biogenesis"
Gene Ontology annotation through association of InterPro records with GO terms
Use of the ND evidence code for Gene Ontology (GO) terms