Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
The transcription factor Sox9 is required for cranial neural crest development in Xenopus.
Sox10 regulates the development of neural crest-derived melanocytes in Xenopus.
Specification of the otic placode depends on Sox9 function in Xenopus.
Early requirement of the transcriptional activator Sox9 for neural crest specification in Xenopus.
SoxE factors function equivalently during neural crest and inner ear development and their activity is regulated by SUMOylation.
Functional analysis of Sox8 during neural crest development in Xenopus.
Lamprey type II collagen and Sox9 reveal an ancient origin of the vertebrate collagenous skeleton.
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Lamprey Sox9 is co-expressed with Col2a1 during skeletogenesis; the chondrogenic programme is conserved across vertebrates.
"the genetic pathway for chondrogenesis is conserved in lampreys and gnathostomes from earliest Sox9 expression through cartilage matrix gene activation"
SoxE gene duplication and development of the lamprey branchial skeleton: Insights into development and evolution of the neural crest.
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Lamprey SoxE1 and SoxE2 are required for specification of the chondrogenic neural crest.
"Our results suggest that SoxE1 and SoxE2 are required for specification of the chondrogenic neural crest"
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SoxE duplications in agnathans and gnathostomes were independent.
"independent evolution of duplicated SoxE genes among agnathan and gnathostome vertebrates"
Novel Tfap2-mediated control of soxE expression facilitated the evolutionary emergence of the neural crest.
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Amphioxus soxE lacks neural crest enhancers and is not co-expressed with AP2; crest recruitment of SoxE was cis-regulatory.
"because AP2 and SoxE are not co-expressed in amphioxus, and because neural crest enhancers are not detected proximal to amphioxus soxE"
UniProt entry B7ZR65 (sox9-a, Xenopus laevis)
Deep research report on Xenopus laevis sox9-a (falcon)