Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Down-regulation of CXCR4 by human herpesvirus 6 (HHV-6) and HHV-7.
Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors.
Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS.
Cutting edge: CXCR4-Lo: molecular cloning and functional expression of a novel human CXCR4 splice variant.
Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization.
Use of chemokine receptors by poxviruses.
beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4.
Engagement of CD28 modulates CXC chemokine receptor 4 surface expression in both resting and CD3-stimulated CD4+ T cells.
HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases.
Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes.
The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4.
Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study.
Constitutive association of cell surface CCR5 and CXCR4 in the presence of CD4.
The multiple personalities of the chemokine receptor CCR7 in dendritic cells.
Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells.
CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow.
CXCR4-CCR5: a couple modulating T cell functions.
Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function.
Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines.
Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation.
The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction.
CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling.
A functional heteromeric MIF receptor formed by CD74 and CXCR4.
Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4.
Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner.
F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse.
CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation.
Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway.
CXCR7/CXCR4 heterodimer constitutively recruits beta-arrestin to enhance cell migration.
Identification and profiling of CXCR3-CXCR4 chemokine receptor heteromer complexes.
CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration.
Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5.
Actin-binding protein drebrin regulates HIV-1-triggered actin polymerization and viral infection.
CD164 regulates the tumorigenesis of ovarian surface epithelial cells through the SDF-1α/CXCR4 axis.
The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4.
The WHIM-like CXCR4(S338X) somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom's Macroglobulinemia.
Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet-induced obesity.
Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine.
Heteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function.
New Insights into Mechanisms and Functions of Chemokine (C-X-C Motif) Receptor 4 Heteromerization in Vascular Smooth Muscle.
Vascular mimicry formation is promoted by paracrine TGF-β and SDF1 of cancer-associated fibroblasts and inhibited by miR-101 in hepatocellular carcinoma.
α(1)-Adrenergic Receptors Function Within Hetero-Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C-X-C motif) Receptor 4 in Vascular Smooth Muscle Cells.
RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling.
Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle.
ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer.
Multiplexed mapping of the interactome of GPCRs with receptor activity-modifying proteins.
Cryo-EM structure of monomeric CXCL12-bound CXCR4 in the active state.
Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes.
The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1.
Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1.
Conformational changes in gp120 exposes gp41
CD4:gp120 binds to chemokine co-receptor CCR5/CXCR4
N and C terminal heptad repeat helices of gp41 form six-helix bundle
Fusogenic activation of gp41
Insertion of gp41 fusion peptide into the target membrane
Fusion of viral membrane with host cell membrane
Receptors CXCR4 and 7 bind CXCL12 ligand
Liganded Gi-activating GPCR acts as a GEF for Gi
The Ligand:GPCR:Gi complex dissociates
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
Expression of CXCR4 in definitive endoderm
Expression of CXCR4 in primordial germ cells
The N-terminus of CXCR4 splice variants determines expression and functional properties.
CXCR4 mediated recognition of HIV envelope spike and inhibition by CXCL12.
CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination.
The chemokine SDF1 regulates migration of dentate granule cells.
Tonic activation of CXC chemokine receptor 4 in immature granule cells supports neurogenesis in the adult dentate gyrus.
CXCR4 source and assay guide
CXCR4 UniProt record (P61073)