Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression.
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.
The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182).
Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner.
POT1 as a terminal transducer of TRF1 telomere length control.
TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres.
The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance.
TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex.
NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
Mitotic phosphorylation of tankyrase, a PARP that promotes spindle assembly, by GSK3.
Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.
Telomere elongation by a mutant tankyrase 1 without TRF1 poly(ADP-ribosyl)ation.
Zinc binding catalytic domain of human tankyrase 1.
MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.
Tankyrase-1 assembly to large protein complexes blocks its telomeric function.
Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.
Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression.
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.
Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.
Tankyrase 1 regulates centrosome function by controlling CPAP stability.
Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation.
Family-wide analysis of poly(ADP-ribose) polymerase activity.
Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.
Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.
Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways.
Architecture of the human interactome defines protein communities and disease networks.
HENA, heterogeneous network-based data set for Alzheimer's disease.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Multimodal cell maps as a foundation for structural and functional genomics.
Tankyrase, a poly(ADP-ribose) polymerase at human telomeres.
RNF146 binds RibC-AXIN:TNKS complex
Tankyrase ADP-ribosylates AXIN
RNF146 ubiquitinates ADP-ribosylated AXIN
USP34 deubiquitinates AXIN1,AXIN2
Ub-RibC-AXIN is degraded by the proteasome
XAV939 binds tankyrase to stabilize axin and inhibit WNT signaling
TNKS and TNKS2 PARylate PTEN
Falcon deep research synthesis for TNKS