Ckmt2 review notes

Evidence summary

• [UniProtKB:P09605] UniProt describes Ckmt2 as reversibly transferring phosphate between ATP and creatine/phosphocreatine for energy transduction.
• PMID:3972849 The fetched GOA file uses this publication for cardiolipin binding, which is kept as non-core membrane-context support rather than the defining function.
• PMID:8086475 The fetched GOA file uses expression evidence for heart and skeletal muscle development terms; these are marked over-annotated because expression/developmental context is not the enzyme core function.

Curation decisions

• Core function: mitochondrial creatine kinase S-type (creatine kinase activity, GO:0004111).
• Specific catalytic activities were accepted; broad parent terms were modified to the specific activity where possible.
• Localization, cofactor/binding, and phenotype-level annotations were retained only as non-core unless directly tied to the enzymatic role.