Gene Ontology annotation through association of InterPro records with GO terms.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
Interaction between Arabidopsis heat shock transcription factor 1 and 70 kDa heat shock proteins.
The calmodulin-binding protein kinase 3 is part of heat-shock signal transduction in Arabidopsis thaliana.
Detection of in vivo interactions between Arabidopsis class A-HSFs, using a novel BiFC fragment, and identification of novel class B-HSF interacting proteins.
Functional characterization of AtHsp90.3 in Saccharomyces cerevisiae and Arabidopsis thaliana under heat stress.
Cytosol-localized heat shock factor-binding protein, AtHSBP, functions as a negative regulator of heat shock response by translocation to the nucleus and is required for seed development in Arabidopsis.
AtHSBP functions in seed development and the motif is required for subcellular localization and interaction with AtHSFs.
Arabidopsis HsfA1 transcription factors function as the main positive regulators in heat shock-responsive gene expression.
Arabidopsis heat shock factor: isolation and characterization of the gene and the recombinant protein.
Interaction between the Arabidopsis thaliana heat shock transcription factor HSF1 and the TATA binding protein TBP.
Deep research document for HSFA1A with 37 citations
Falcon (Edison Scientific) deep research report for HSFA1A (AT4G17750, P41151)
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"**HSFA1A encodes a sequence-specific transcription factor** that initiates and shapes the plant **heat stress response (HSR)** by binding heat-responsive promoter elements and inducing canonical protective programs (notably heat shock proteins, other HSFs, and additional stress TFs)."
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"HSFA1 family members are widely described as the **top tier (“master regulators”)** in an HSF regulatory hierarchy."
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"A widely used model for plant HSFA1 activation is **chaperone-mediated repression** at ambient temperature: HSFA1 proteins can be held inactive through interactions with **HSP70/HSP90**, and heat-induced protein misfolding titrates chaperones away, permitting HSFA1 activation."
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"A notable Arabidopsis-specific feature emphasized by recent primary work is that **AtHSFA1a is predominantly nuclear even under non-stress conditions**."
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"A 2024 mechanistic study reports that **HOP (HSP70–HSP90 organizing protein; HOP1/2/3)** physically interacts with HSFA1a in planta, with interaction signals detected predominantly in the nucleus, and that HOP is required to maintain HSFA1a protein accumulation."
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"In hop1 hop2 hop3 mutants, HSFA1a protein accumulation is reduced and can be restored by the **proteasome inhibitor MG132** or by a **chemical chaperone (TUDCA)**, supporting a model in which HOP promotes HSFA1a folding/stability and prevents proteasome-dependent loss."
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"Other transcription factors** such as **DREB2A**, multiple HSFs (including **HSFA2**, **HSFA7A/B**), and **MBF1C**."
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"In the thermomorphogenesis context (mild, sustained warm temperature), **prior ChIP-seq work (cited in 2024 primary data)** identified **1,371 direct HSFA1a targets**."