Gene Ontology annotation through association of InterPro records with GO terms
Use of the ND evidence code for Gene Ontology (GO) terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Nonorthologous gene displacement of phosphomevalonate kinase.
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Phosphomevalonate kinase catalyzes phosphorylation of 5-phosphomevalonate to 5-diphosphomevalonate in the mevalonate pathway.
"Phosphomevalonate kinase (PMK; EC 2.7.4.2) catalyzes the phosphorylation of 5-phosphomevalonate into 5-diphosphomevalonate, an essential step in isoprenoid biosynthesis via the mevalonate pathway."
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ERG8-type PMKs occur in eubacteria, fungi and plants, whereas animal PMVK enzymes are nonorthologous.
"orthologues of ERG8 are present in eubacteria, fungi, and plants, while orthologues of human PMK are found only in animals"
Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1.
Antifungal activity of fluconazole in combination with lovastatin and their effects on gene expression in the ergosterol and prenylation pathways in Candida albicans.
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The C. albicans sterol pathway includes intermediates used for ergosterol, prenylation and dolichol synthesis.
"Intermediates in the sterol pathway are involved in ergosterol synthesis, prenylation and dolichol synthesis."
UniProt entry A0A1D8PLH0 (ERG8_CANAL)
PAINT IBD nodes for PTHR31814