Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
YeastPathways to GO-CAM conversion
Absence of cardiolipin in the crd1 null mutant results in decreased mitochondrial membrane potential and reduced mitochondrial function.
Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.
Cardiolipin mediates cross-talk between mitochondria and the vacuole.
Biochemical characterization and regulation of cardiolipin synthase in Saccharomyces cerevisiae.
Structural and mechanistic insights into phospholipid transfer by Ups1-Mdm35 in mitochondria.
Misregulation of a DDHD Domain-containing Lipase Causes Mitochondrial Dysfunction in Yeast.
Kinetic analysis of cardiolipin synthase: a membrane enzyme with two glycerophospholipid substrates.
Cardiolipin synthase from yeast.
Isolation and characterization of the gene (CLS1) encoding cardiolipin synthase in Saccharomyces cerevisiae.
UniProtKB entry Q07560 (CRLS1_YEAST)
SGD gene description for CRD1 (yeast)
Cardiolipin and mitochondrial phosphatidylethanolamine have overlapping functions in mitochondrial fusion in Saccharomyces cerevisiae.
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Cardiolipin and mitochondrial PE are redundantly required for tubular mitochondrial morphology and fusion; loss of cardiolipin alone does not fragment the network.
"In the presence of tetracycline, the mutant exhibited highly fragmented mitochondria, loss of mitochondrial DNA, and reduced membrane potential, characteristic of fusion mutants."
Genome-Wide Screens in Saccharomyces cerevisiae Highlight a Role for Cardiolipin in Biogenesis of Mitochondrial Outer Membrane Multispan Proteins.
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crd1 null mitochondria have reduced levels and import of outer-membrane multispan proteins but not of single-span proteins.
"Our results indeed demonstrate lower steady-state levels of the multispan proteins Ugo1, Scm4, and Om14 in mitochondria from crd1Δ cells."