Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Oncogenic stress-induced Netrin is a humoral signaling molecule that reprograms systemic metabolism in Drosophila.
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Tumour (RasV12)-derived NetrinB acts via Unc-5 to suppress TMLHE (Tmlh) transcription in the fat body, reducing carnitine and acetyl-CoA production; fat-body Tmlh knockdown aggravates survival under oncogenic stress, and carnitine or acetyl-CoA supplementation rescues.
"TMLHE knockdown in the fat body aggravates organismal survival over the oncogenic stress."
UniProtKB Q9VDM7 (Tmlh, Drosophila melanogaster) TrEMBL record
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Unreviewed entry naming the protein mitochondrial trimethyllysine dioxygenase (EC 1.14.11.8, RHEA:14181), Fe(II) and ascorbate cofactors, carnitine biosynthesis pathway, gamma-BBH/TMLD family; functional statements are ARBA rule-based.
"Converts trimethyllysine (TML) into hydroxytrimethyllysine"
L-Carnitine in Drosophila: A Review.
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Review of carnitine metabolism in Drosophila; identifies CG4335 (Tmlh) as the putative TMLH ortholog and notes it was uncharacterized at the time.
"Blast analysis indicates that in Drosophila, Dmel/CG4335 is the putative orthologous gene, which is an uncharacterized gene harbored on the right arm of chromosome 3."