asna-1 review notes

• 2026-10-28: Created review. just fetch-gene worm asna-1 timed out on the UniProt
  symbol search; re-ran with --uniprot-id P30632, which resolved correctly
  (ASNA_CAEEL, 342 aa, 17 GOA rows).
• No deep-research API keys; manual research in asna-1-deep-research-manual.md.
• PMID:23705068 was flagged by the workflow as a key paper. Full text read: it mentions
  asna-1 only as a control strain (Figure 4-figure supplement 3E) PMID:23705068.
  Not used to support any annotation; relevance LOW.

Decisions

• Core: ATP hydrolysis activity (IDA x2, IBA, IEA all ACCEPT); TA protein insertion into
  ER membrane (IBA, ISS ACCEPT; worm IMP-quality evidence in PMID:33883621); GET complex
  (IBA ACCEPT; WRB-1 co-IP in worm).
• protein binding (Y2H with CEE-1) x2: REMOVE per protein-binding policy.
• protein insertion into ER membrane (IEA): MODIFY -> GO:0071816 (already present).
• Insulin secretion IMP and neuronal localizations (axon, cell body): KEEP_AS_NON_CORE.
  The insulin role is genetically separable from TA targeting (wrb-1 mutants normal) and
  its mechanism is unknown.
• Arsenic detoxification IMP: KEEP_AS_NON_CORE; sensitivity phenotype real, but whether
  ASNA-1 itself performs detoxification (as bacterial ArsA does with ArsB) is not shown.
• NEW: GO:0140597 protein carrier activity (ISS to human/yeast GET3, plus worm SEC-61beta
  co-IP); GO:0005794 Golgi apparatus (IDA, PMID:36939052).
• Did not add NEW process terms for cisplatin response, L1 growth, etc. (phenotype only).