Gene Ontology annotation through association of InterPro records with GO terms
Use of the ND evidence code for Gene Ontology (GO) terms
Annotation inferences using phylogenetic trees
Current PAINT annotations for PTHR21646
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Current PTHR21646 PAINT places nuclear localization at PTN002541993.
"PTHR21646 PTN002541993 GO:0005634 C IBD false AGI_LocusCode:AT1G17110|AGI_LocusCode:AT2G22310|AGI_LocusCode:AT3G11910|AGI_LocusCode:AT3G14400|AGI_LocusCode:AT4G39910|AGI_LocusCode:AT5G06600|AGI_LocusCode:AT5G57990|FB:FBgn0016756|FB:FBgn0030366|FB:FBgn0039214|FB:FBgn0260936|MGI:MGI:2182061|PomBase:SPAC13A11.04c|PomBase:SPBC713.02c|PomBase:SPCC1682.12c|SGD:S000005130|UniProtKB:O75317|UniProtKB:O94782|UniProtKB:P45974|UniProtKB:Q0E2F9|UniProtKB:Q0WX57|UniProtKB:Q14694|UniProtKB:Q385P1|UniProtKB:Q38F03|UniProtKB:Q582C5|UniProtKB:Q6QN14|UniProtKB:Q6R6M4|UniProtKB:Q86T82|UniProtKB:Q86UV5|UniProtKB:Q8NB14|UniProtKB:Q93009|UniProtKB:Q96K76|UniProtKB:Q96RU2|UniProtKB:Q9BXU7|UniProtKB:Q9P275|UniProtKB:Q9UMW8|UniProtKB:Q9UPU5|WB:WBGene00009267|WB:WBGene00010406 taxon: 20260529"
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Current PTHR21646 PAINT places cytosol at PTN002541993.
"PTHR21646 PTN002541993 GO:0005829 C IBD false AGI_LocusCode:AT4G17895|FB:FBgn0016756|FB:FBgn0030366|SGD:S000000953|SGD:S000004920|UniProtKB:Q14694|UniProtKB:Q86UV5|UniProtKB:Q93008|UniProtKB:Q93009|UniProtKB:Q9UHP3|UniProtKB:Q9UMW8|UniProtKB:Q9UPU5 taxon: 20251220"
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Current PTHR21646 PAINT places cysteine-type deubiquitinase activity at PTN002541993.
"PTHR21646 PTN002541993 GO:0004843 F IBD false AGI_LocusCode:AT1G04860|AGI_LocusCode:AT1G17110|AGI_LocusCode:AT2G22310|AGI_LocusCode:AT3G11910|AGI_LocusCode:AT4G24560|AGI_LocusCode:AT4G39370|AGI_LocusCode:AT4G39910|AGI_LocusCode:AT5G06600|FB:FBgn0005632|FB:FBgn0016756|FB:FBgn0030366|FB:FBgn0033738|FB:FBgn0260936|MGI:MGI:107697|MGI:MGI:107698|MGI:MGI:107699|MGI:MGI:1888998|MGI:MGI:1924050|MGI:MGI:2140991|MGI:MGI:2182061|MGI:MGI:3051372|MGI:MGI:3051498|MGI:MGI:894681|PomBase:SPAC13A11.04c|PomBase:SPBC713.02c|PomBase:SPBP8B7.21|PomBase:SPCC188.08c|RGD:1306915|RGD:1564808|RGD:735213|SGD:S000000163|SGD:S000000262|SGD:S000000953|SGD:S000001418|SGD:S000001806|SGD:S000002280|SGD:S000004920|SGD:S000005130|SGD:S000005650|UniProtKB:O00507|UniProtKB:O75317|UniProtKB:O94782|UniProtKB:P45974|UniProtKB:P62068|UniProtKB:Q0E2F9|UniProtKB:Q0WX57|UniProtKB:Q14694|UniProtKB:Q6QN14|UniProtKB:Q6R6M4|UniProtKB:Q70CQ2|UniProtKB:Q70CQ3|UniProtKB:Q86T82|UniProtKB:Q86UV5|UniProtKB:Q8NB14|UniProtKB:Q92995|UniProtKB:Q93008|UniProtKB:Q93009|UniProtKB:Q96K76|UniProtKB:Q96RU2|UniProtKB:Q96V54|UniProtKB:Q9BXU7|UniProtKB:Q9H9J4|UniProtKB:Q9NVE5|UniProtKB:Q9P275|UniProtKB:Q9P2H5|UniProtKB:Q9UHP3|UniProtKB:Q9UMW8|WB:WBGene00010406|WB:WBGene00011216|ZFIN:ZDB-GENE-060526-335|dictyBase:DDB_G0291239 taxon: 20260529"
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Current PTHR21646 PAINT places regulation of protein stability at PTN002541993.
"PTHR21646 PTN002541993 GO:0031647 P IBD false AGI_LocusCode:AT3G11910|AGI_LocusCode:AT5G06600|FB:FBgn0016756|FB:FBgn0039214|MGI:MGI:1888998|MGI:MGI:1919594|MGI:MGI:2182061|RGD:1306915|UniProtKB:Q92995|UniProtKB:Q93008|UniProtKB:Q93009|UniProtKB:Q96RU2|UniProtKB:Q9P275 taxon: 20260529"
Combined Automated Annotation using Multiple IEA Methods
Chemically synthesized ubiquitin extension proteins detect distinct catalytic capacities of deubiquitinating enzymes.
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Recombinant yeast Ubp11p was among the DUBs assayed against synthetic ubiquitin substrates and cleaved ubiquitin fusions, but isopeptidase activity was associated only with a different subset (Yuh1p, Unp, Ubp1p, Ubp2p), so UBP11's physiological linkage specificity is not defined here.
Analysis of the deubiquitinating enzymes of the yeast Saccharomyces cerevisiae.
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All 17 yeast DUB genes were individually deleted; none of the single mutants is lethal or strongly growth-defective under standard conditions, and 14 of 17 DUBs (including Ubp11p) have demonstrated ubiquitin-cleaving activity — establishing both the DUB activity and the lack of a strong single-deletion phenotype for UBP11.
The cellular economy of the Saccharomyces cerevisiae zinc proteome.
UBP11 USP catalytic-domain integrity analysis (this repository)
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Reproducible parse of the UniProt record confirms the USP catalytic dyad (nucleophile Cys307, proton acceptor His649) is intact within a 410-aa peptidase C19 domain, supporting a catalytically competent deubiquitinase.
yeast/UBP11/UBP11-notes.md