Sources: UniProt Q9FF75/Q9SG79 entries, GOA-cited publications in publications/. Full text cached for
PMID:22270916, PMID:24667841, PMID:24891605, PMID:25330379, PMID:25759303; abstract-only for PMID:19807882,
PMID:21294795, PMID:25217773, PMID:25412930, PMID:27630107, PMID:23973298, PMID:15469496. Falcon deep research
not available at time of review.
Key findings
- Cter-SUN, type II INM protein; coiled coil drives homo/heteromers with its paralog
PMID:19807882.
- SUN domain binds plant KASH proteins WIP1-3 PMID:22270916,
SINE1-4 via conserved KASH pocket PMID:24891605, and TIK (PMID:25217773).
- SUN required for WIP1/RanGAP1 NE retention PMID:22270916.
- Nuclear shape: SUN-WIP-WIT2-myosin XI-i bridge PMID:25759303;
SUN1 predominant PMID:25759303.
- Nuclear POSITION is not affected in sun1-KO sun2-KD PMID:22270916
-> no nuclear migration annotation proposed; relevant to the nucleokinesis module (plant nuclear movement is actomyosin/WIT/myosin XI-i driven).
- Meiosis: NE in prophase I; double mutant synapsis/chiasma defects PMID:25412930.
- SUN recruits CRWN1/LINC1 on overexpression (PMID:24667841) but SUN and CRWN1 act independently on nuclear shape in planta (PMID:25759303).
Decisions
- Protein binding: KASH partners (WIP/SINE/TIK) -> MODIFY to GO:0140444 (consistent with human SUN1/SUN2 reviews);
SUN-SUN, SUN3/4, CRWN1, NEAP1 -> REMOVE (uninformative; oligomerization / NE localization captured elsewhere).
- ER / ER membrane / phragmoplast -> KEEP_AS_NON_CORE (mitotic/transit locations).
- GO:2000769 (SUN1 only) -> MODIFY to GO:0006997: the paper measures nuclear, not cell, shape/polarity.
- Spindle HDA (SUN2 only) -> UNDECIDED (abstract-only GFP survey).
- Complex: GO:0106094 is microtubule-specific; plant bridge is actin/myosin XI-i-linked, so core function uses GO:0106083.