elg1 (Q86BP6) curation notes
- Ortholog of yeast Elg1 / human ATAD5; AAA+ large subunit of the Elg1 RFC-like complex (PCNA unloader).
- Complex: PMID:27198229.
- Function in flies: PMID:27198229. Enok complex binds via Br140 and inhibits unloading to promote G1/S.
- Germline: PMID:24531791; PMID:27198229.
- NAS row for DNA strand elongation cites PMID:24204884 (Elongin/Corto), which does not mention Elg1; MODIFY to GO:0006261 since Elg1 acts after elongation (unloading).
- GO:0061860 IBA (donor ATAD5) accepted; core function recorded as contributes_to with GO:0031391.
- Round-2 rule applied: generic parents (DNA replication, ATP-dependent activity acting on DNA, protein-containing complex) changed from KEEP_AS_NON_CORE to MODIFY toward the specific term the gene already carries; subunit-level binding/ATPase terms stay KEEP_AS_NON_CORE.
- Falcon deep research (arrived late) gives an accurate orthology-based picture (Elg1-RFC/ATAD5-RFC unloader structures, Xenopus Atad5-RLC as main unloader) but overlooked PMID:27198229, so it understates direct fly evidence.