Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Functional analysis of the profilaggrin N-terminal peptide: identification of domains that regulate nuclear and cytoplasmic distribution.
Analysis of epidermal-type transglutaminase (transglutaminase 3) in human stratified epithelia and cultured keratinocytes using monoclonal antibodies.
Characterization of the human epidermal profilaggrin gene. Genomic organization and identification of an S-100-like calcium binding domain at the amino terminus.
Role of ADAM-9 disintegrin-cysteine-rich domains in human keratinocyte migration.
Filaggrin in the frontline: role in skin barrier function and disease.
Proteomic characterization of the human sperm nucleus.
Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin.
Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.
Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes.
Crystal Structure of Human Profilaggrin S100 Domain and Identification of Target Proteins Annexin II, Stratifin, and HSP27.
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
Liquid-liquid phase separation drives skin barrier formation.
Structural properties of target binding by profilaggrin A and B domains and other S100 fused-type calcium-binding proteins.
Characterization of a class of cationic proteins that specifically interact with intermediate filaments.
Histidine-rich proteins (filaggrins): structural and functional heterogeneity during epidermal differentiation.
The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope.
The mechanism of interaction of filaggrin with intermediate filaments. The ionic zipper hypothesis.
Profilaggrin is a major epidermal calcium-binding protein.
Translocation of profilaggrin N-terminal domain into keratinocyte nuclei with fragmented DNA in normal human skin and loricrin keratoderma.
Fillagrin and keratin intermediate filaments polymerize forming a network
Lamellar bodies bind the early cornified envelope
Reinforcement of the Cornified Envelope
Late envelope proteins bind cornified envelope:CDSN
CDSN binds the cornified envelope
Membrane proteases cleave Profilaggrin producing Filaggrin
Cytoplasmic proteases cleave Profilaggrin producing Filaggrin
Filaggrin binds Keratin tonofilament:Desmosome
OpenScientist hypothesis report: FLG has calcium ion binding (GO:0005509)
OpenScientist hypothesis report: the molecular function of the mature filaggrin repeat unit is keratin intermediate filament binding, not structural molecule activity
OpenScientist hypothesis report: FLG has transition metal ion binding (GO:0046914)