Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
The MexJK efflux pump of Pseudomonas aeruginosa requires OprM for antibiotic efflux but not for efflux of triclosan.
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Triclosan efflux requires MexJ and MexK but no outer membrane channel.
"Triclosan efflux required neither of the outer membrane protein channels tested but necessitated the MexJ membrane fusion protein and the MexK inner membrane RND transporter."
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MexJK exports tetracycline and erythromycin with OprM.
"The MexJK system effluxed tetracycline and erythromycin but only in the presence of the outer membrane protein channel OprM"