The review YAML is the authority for final decisions. FGB supplies beta-chain structure to fibrinogen and fibrin. Its contextual platelet, cell-adhesion, chaperone-client and extracellular-fraction associations are distinguished from an autonomous beta-chain catalytic or receptor-binding function.
The literature journal, direct evidence guide and database evidence guide describe the experiments and source limits. The review contains 113 decisions, 82 complete reference assessments, one structural core and two separately described cleavage products. All imported source identities/order remain unchanged; no NEW assertion or publication quotation is added.
The final normal-source set contains 80 genuine files: 33 publications, 44 Reactome entries and three unchanged PANTHER/PAINT files. The other 29 discovery sources remain private and unchanged. Current family identifiers are preserved alongside explicit evidence from the older API tree and exact human sequence; the version difference is not hidden by replacing the accepted normal files.
The decisions comprise 65 ACCEPT, 28 KEEP_AS_NON_CORE, five TOO_GENERAL, one MODIFY and 14 UNDECIDED. The modified cortex assertion is replaced by an evidence-supported external-surface location. A positive generic binding association remains non-core under the standing project instructions. Same-term action differences preserve distinctions between generic structural biology and unresolved source-specific high-throughput observations.
The core uses GO:0072378, blood coagulation, fibrin clot formation, matching the accepted FGB process assertions and its structural contribution to the fibrin network. This is a scope alignment with the evidence, not a claim that pathway participation requires catalysing every step. The ontology evidence records the selection.
Four HDA rows remain UNDECIDED because the particular FGB/sample identifications were not recovered: the bone-marrow structural-constituent and matrix records, the colostrum extracellular record, and the cultured-cell matrix record. Independently supported extracellular and structural biology remains accepted elsewhere. The uncertainty concerns those original experimental records; it does not deny the generic gene-level claims.