GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:10862717

Identification and molecular-genetic characterization of a LAMP/CD68-like protein from Caenorhabditis elegans.

LMP-1 is a LAMP/CD68-like protein carrying a C-terminal GYXX(phi) lysosomal targeting motif, localized to the periphery of intestinal granules; lmp-1 mutants are viable but lose one granule type.

PMID:18256195

C. elegans Rab GTPase 2 is required for the degradation of apoptotic cells.

LMP-1 is found on phagosomes together with UNC-108, RAB-5 and RAB-7.

PMID:19403699

Normal formation of a subset of intestinal granules in Caenorhabditis elegans requires ATP-binding cassette transporters HAF-4 and HAF-9, which are highly homologous to human lysosomal peptide transporter TAP-like.

LMP-1::mRFP marks nonacidic late lysosomes in adult intestine; lmp-1 mutants show aberrant membrane-limited vacuoles.

PMID:20133524

Retromer is required for apoptotic cell clearance by phagocytic receptor recycling.

PMID:22225878

Lysosome-related organelles in intestinal cells are a zinc storage site in C. elegans.

LMP-1 localizes to gut granule membranes (one lobe of bilobed granules under high zinc) and to the plasma membrane.

PMID:22916203

C. elegans BLOC-1 functions in trafficking to lysosome-related gut granules.

LMP-1 is mainly on conventional lysosomes in embryonic intestine, partly on RAB-7 late endosomes, on basolateral plasma membrane and on PGP-2 gut granules; AP-3 is needed for its delivery to gut granules.

PMID:23705068

A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans.

LMP-1::GFP is used as a lysosome marker; no information about LMP-1 function.

PMID:26783301

Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.

LMP-1::GFP labels late endosomes/lysosomes in coelomocytes.

PMID:27810910

The lysosomal membrane protein SCAV-3 maintains lysosome integrity and adult longevity.

LMP-1/LMP-2 overexpression suppresses lysosomal membrane damage in scav-3 mutants, while their loss does not severely affect lysosome integrity.

file:worm/lmp-1/lmp-1-uniprot.txt

UniProt entry Q11117