Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Towards a proteome-scale map of the human protein-protein interaction network.
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High-throughput yeast two-hybrid interactome map; source of bare protein binding annotations for CHIC2 with no specific functional partner established.
"Towards a proteome-scale map of the human protein-protein interaction network."
An empirical framework for binary interactome mapping.
A proteome-scale map of the human interactome network.
Network-based prediction of protein interactions.
A reference map of the human binary protein interactome.
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HuRI reference binary interactome; contributes the bulk of CHIC2's high-throughput Y2H interactors, dominated by promiscuous preys.
"A reference map of the human binary protein interactome."
A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif.
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CHIC2 is palmitoylated within the CHIC motif; palmitoylation is required for membrane association, and CHIC2 localizes to the cell membrane and cytoplasmic vesicles including a Golgi-like vesicular compartment.
"Palmitoylation in the CHIC motif is required for membrane association."
UniProt entry CHIC2_HUMAN (Q9UKJ5)
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Documents CHIC2 subcellular localization (cell membrane, cytoplasmic vesicle, Golgi-like vesicular compartment), palmitoylation in the CHIC motif required for membrane association, and the t(4;12) translocation with ETV6.
"SUBCELLULAR LOCATION; Cell membrane {ECO:0000269|PubMed:11257495}. Cytoplasmic vesicle {ECO:0000269|PubMed:11257495}."