liuA (PA2015, Q9I296) notes

Literature

No deep-research provider was available. PMC full text of PMID:16517656 was not returned by the PubMed
tool. Sources: cached abstracts of PMID:18625020, PMID:16517656 and PMID:16272386.

Purified LiuA PMID:18625020; terpene-derived acyl-CoAs
not used PMID:18625020.
Atu enters Liu downstream of LiuA PMID:16272386. Yet all liu mutants, including a
complemented liuA mutant, fail on terpenes PMID:18625020.

PseudoCAP IBA-seed assessment

PTN node	node term	n_seeds	leaf IBAs	seed annotation (term, evidence, PMID)	verdict	rationale	other seeds	IBD stands without this seed?
PTN000744030	GO:0003995 acyl-CoA dehydrogenase activity	14	101 (51 taxa)	GO:0008470, IDA, PMID:18625020 (PseudoCAP)	SOUND	Abstract reports the purified-enzyme assay with Km.	human IVD P26440, SBCAD P45954, SCAD P16219, VLCAD P49748, ACAD9 Q9H845, rat/mouse ACADs, Arabidopsis AT3G45300, Aspergillus C8VQF1, bovine Q3ZBF6	Yes. Thirteen other characterised ACADs; the broad node term suits a broad ACAD clade.
PTN000744030	GO:0003995 acyl-CoA dehydrogenase activity	14	101 (51 taxa)	GO:0008470, IMP, PMID:16517656 (PseudoCAP)	UNVERIFIABLE	Abstract describes atuF/liuD/liuE mutant phenotypes, not a liuA mutant or an IVD assay; full text unavailable. The term itself is right (IDA above), so no defect.	as above	Yes.

No PSEUDOCAP or GO_CENTRAL defect on the seed rows. One UNIPROT defect (CONFIRMED): the ARBA RecName
"Isovaleryl-CoA dehydrogenase, mitochondrial" on a bacterial protein.

Other decisions

GO:0008300 isoprenoid catabolic process (PseudoCAP IMP): MARK_AS_OVER_ANNOTATED. LiuA's step is upstream
of the Atu entry point and LiuA does not use the terpene acyl-CoAs tested; the terpene growth defect is
unexplained necessity. This differs deliberately from liuC (MODIFY to GO:0016100) and liuE
(TOO_GENERAL), which act downstream of the entry point. Raised as a suggested question.
GO:0003995 (IBA, IEA), GO:0016627: TOO_GENERAL (GO:0008470 is_a GO:0003995, checked).