Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Combined Automated Annotation using Multiple IEA Methods
Three proteins define a class of human histone deacetylases related to yeast Hda1p.
Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region.
MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.
Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.
Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity.
ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis.
NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development.
Defining the membrane proteome of NK cells.
Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4.
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes.
The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.
NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment.
PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex.
RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene.
The functional interactome landscape of the human histone deacetylase family.
NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination.
Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.
The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation.
Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.
De Novo Mutations in CHD4, an ATP-Dependent Chromatin Remodeler Gene, Cause an Intellectual Disability Syndrome with Distinctive Dysmorphisms.
ZMYND8 Co-localizes with NuRD on Target Genes and Regulates Poly(ADP-Ribose)-Dependent Recruitment of GATAD2A/NuRD to Sites of DNA Damage.
CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.
Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.
Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex.
Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.
ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression.
ZNF410 represses fetal globin by singular control of CHD4.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Multimodal cell maps as a foundation for structural and functional genomics.
Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen.
Characterization of the CHD family of proteins.
The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.
Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.
HDAC1:2-containing complex deacetylate histones
MTA2-NuRD complex deacetylates TP53
SALL4 recruits NuRD to PTEN gene
NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression
EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions
HDAC1:2-containing complex binds HDAC2 Inhibitors
CHD and CDK2AP subunits are recruited to NuRD
Formation of ChAHP complex
GATAD2A NuRD binds ZMYND8:ZNF532:ZNF592:ZNF687
ZNF827 and NR2C2,NR2F2 recruit NuRD to telomeric chromatin
NuRD deacetylates telomeric nucleosomes
NuRD hydrolyzes ATP to affect nucleosome organization
NuRD deacetylates nucleosomes
NuRD binds TCF19 at FBP1 gene
NuRD binds TCF19 at G6PC gene
NuRD binds TCF19 at PCK1 gene
NuRD binds Ikaros family member proteins
Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations.
The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements.
Remodeling activity of ChAHP restricts transcription factor access to chromatin.
Active gene repression by the Egr2.NAB complex during peripheral nerve myelination.
Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain.
CHD4 source-linked interaction, donor, localization and primary-access evidence
Structural and functional insights into the human Börjeson-Forssman-Lehmann syndrome-associated protein PHF6.
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors.
Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation.